The 1987 film Full Metal Jacket portrays the Marines of Hotel Company 2/5 during the Battle of Hue.
The W.E.B. Griffin novel series The Corps featured Marines from 2/5 and their actions during the Battle of Guadalcanal.
The 2011 film Battle: Los Angeles portrays the Marines of 2/5 in a fictional Battle of Los Angeles inspired by the 1942 events.
The 2013 National Geographic Channel series Battleground Afghanistan follows Golf Company, 2nd Battalion, 5th Marines as they continue the fight in Afghanistan while other units withdraw from Afghanistan in 2012.